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Article

Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates.

Immunogenetics - 15 Dec 2025

Aartse Aafke, Bakx Jacco G J, Mortier Daniella, Hofman Sam, Mooij Petra, Claireaux Mathieu, Eggink Dirk, Bogers Willy M, Remarque Edmond J, Corcoran Martin M, Karlsson Hedestam Gunilla B, Bontrop Ronald E, van Gils Marit J, Koopman Gerrit

Abstract excerpt

Non-human primates are important for preclinical vaccine evaluation. In depth characterization of the antibody response requires representative immunoglobulin (IG) germline gene databases for correct gene and allele assignments and assessment of affinity maturation of antigen-specific antibodies. Current IG-reference databases do not cover the genetic diversity observed in frequently used macaque species and it...

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PMID: 41392054
DOI: 10.1007/s00251-025-01392-w
PMCID: PMC12702801

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