Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity.

doi:10.1016/j.immuni.2025.12.002

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Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity.

Immunity - 13 Jan 2026

Peres Ayelet, Upadhyay Amit A, Klein Vered, Saha Swati, Rodriguez Oscar L, Vanwinkle Zachary M, Karunakaran Kirti, Metz Amanda, Lauer William, Lin Mark C, Melton Timothy, Granholm Lukas, Polak Pazit, Peterson Samuel M, Peterson Eric J, Raju Nagarajan, Shields Kaitlyn, Schultze Steven, Ton Thang, Ericsen Adam J, Lapp Stacey A, Villinger Francois, Ohlin Mats, Cottrell Christopher A, Amara Rama R, Derdeyn Cynthia A, Crotty Shane, Schief William R, Karlsson Hedestam Gunilla B, Smith Melissa L, Lees William, Watson Corey T, Yaari Gur, Bosinger Steven E

Abstract excerpt

Rhesus macaques (RMs) are a vital model for studying human disease and are invaluable to preclinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for antibody-encoding genes within the immunoglobulin (IG) loci. The complexity of the IG loci has historically made them challenging to characterize accurately. To address this,...

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PMID: 41494536
DOI: 10.1016/j.immuni.2025.12.002
PMCID: PMC13502367

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