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Article

Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.

Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2024

Schaefer Benedikt, Pammer Lorenz M, Pfeifer Bernhard, Neururer Sabrina, Troppmair Maria R, Panzer Marlene, Wagner Sonja, Pertler Elke, Gieger Christian, Kronenberg Florian, Lamina Claudia, Tilg Herbert, Zoller Heinz

Abstract excerpt

BACKGROUND AND AIMS: Haemochromatosis is characterized by progressive iron overload affecting the liver and can cause cirrhosis and hepatocellular carcinoma. Most haemochromatosis patients are homozygous for p.C282Y in HFE, but only a minority of individuals with this genotype will develop the disease. The aim was to assess the penetrance of iron overload, fibrosis, hepatocellular carcinoma and life expectancy....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38263707
DOI: 10.1111/liv.15797

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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