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Article

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer.

Hepatology (Baltimore, Md.) - 1 Apr 2010

Osborne Nicholas J, Gurrin Lyle C, Allen Katrina J, Constantine Clare C, Delatycki Martin B, McLaren Christine E, Gertig Dorota M, Anderson Gregory J, Southey Melissa C, Olynyk John K, Powell Lawrie W, Hopper John L, Giles Graham G, English Dallas R

Abstract excerpt

UNLABELLED: The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Melbourne Collaborative Cohort Study is a prospective cohort study that commenced recruitment in 1990. Participants born in Australia, New Zealand, the United...

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Source

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Identifiers

PMID: 20099304
DOI: 10.1002/hep.23448
PMCID: PMC3815603

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20099304-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer.PMID 20099304Read ↗

Cancer risk in HFE C282Y homozygotes: results from the HUNT 2 study.Semantic proximity Read ↗

Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy.Semantic proximity Read ↗

Hereditary haemochromatosis beyond liver cancer: increased risk of prostate cancer during an 11-year follow-upSemantic proximity Read ↗

The risk of new-onset cancer associated with HFE C282Y and H63D mutations: evidence from 87,028 participants.Semantic proximity Read ↗

Hereditary Hemochromatosis Variant Associations with Incident Nonliver Malignancies: 11-Year Follow-up in UK Biobank.Semantic proximity Read ↗

Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.Semantic proximity Read ↗

HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis.Semantic proximity Read ↗

Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes: prospective cohort study in UK BiobankSemantic proximity Read ↗

HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank.Semantic proximity Read ↗

Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers.Semantic proximity Read ↗

Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK BiobankSemantic proximity Read ↗

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