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Article

Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers.

Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2021

Hagström Hannes, Ndegwa Nelson, Jalmeus Molly, Ekstedt Mattias, Posserud Iris, Rorsman Fredrik, Nyhlin Nils, Klintman Daniel, Werner Mårten, Marschall Hanns-Ulrich, Askling Johan, Stål Per

Abstract excerpt

BACKGROUND & AIMS: Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk of extra-hepatic diseases, especially breast and colorectal cancer. Here we investigated long-term outcomes of Swedish patients with HFE mutations. METHODS: We identified 3645 patients with a homozygous p.C282Y (62%) or a compound heterozygous p.C282Y/p.H63D (38%) mutation from...

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Identifiers

PMID: 33450138
DOI: 10.1111/liv.14792

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