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Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes: prospective cohort study in UK Biobank

2025-08-26

Abstract excerpt

<h4>Background</h4> The iron overload disease haemochromatosis is primarily caused by HFE p.C282Y homozygosity, yet penetrance of clinical outcomes (including liver disease/cancer) varies. We estimated the effect of genetic and lifestyle factors on disease penetrance and expressivity in C282Y homozygotes. <h4>Methods</h4> We analysed 2,893 C282Y homozygous UK Biobank participants (n=1,295 male). We ascertained h...

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Literature Corpus work
c4ae01c8-989e-50ef-8949-20995a421426
DOI
10.1101/2025.08.22.25334187
Open publication

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Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes: prospective cohort study in UK BiobankDOI 10.1101/2025.08.22.25334187
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