Article
Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis.
Cancer - 15 Jul 2021
McAlpine Jessica N, Chiu Derek S, Nout Remi A, Church David N, Schmidt Pascal, Lam Stephanie, Leung Samuel, Bellone Stefania, Wong Adele, Brucker Sara Y, Lee Cheng Han, Clarke Blaise A, Huntsman David G, Bernardini Marcus Q, Ngeow Joanne, Santin Alessandro D, Goodfellow Paul, Levine Douglas A, Köbel Martin, Kommoss Stefan, Bosse Tjalling, Gilks C Blake, Talhouk Aline
Abstract excerpt
BACKGROUND: Endometrial cancers (ECs) with somatic mutations in DNA polymerase epsilon (POLE) are characterized by unfavorable pathological features, which prompt adjuvant treatment. Paradoxically, women with POLE-mutated EC have outstanding clinical outcomes, and this raises concerns of overtreatment. The authors investigated whether favorable outcomes were independent of treatment. METHODS: A PubMed search for...
Topics
- DNA Polymerase II
- Endometrial Neoplasms
- Female
- Humans
- Mutation
- Poly-ADP-Ribose Binding Proteins
- Prognosis