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Article

Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy.

Histopathology - 1 May 2016

Bakhsh Salwa, Kinloch Mary, Hoang Lien N, Soslow Robert A, Köbel Martin, Lee Cheng-Han, McAlpine Jessica N, McConechy Melissa K, Gilks C Blake

Abstract excerpt

AIMS: To characterize the histomorphological features of endometrial carcinomas (ECs) harbouring polymerase ε (POLE) mutations. METHODS AND RESULTS: Forty-three ECs with POLE mutations were compared with a cohort of 202 ECs. Most POLE-mutated ECs were endometrioid [34/43 (79%)]; the remaining tumours were mixed [6/43 (14%)], serous [2/43 (5%)], and clear cell [1/43 (2%)]. The endometrioid carcinomas were...

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Share to Adenocarcinoma, Clear Cell
Share to Carcinoma, Endometrioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemotherapy, Adjuvant

Share to Cystadenocarcinoma, Serous

Share to DNA Polymerase II

Share to Poly-ADP-Ribose Binding Proteins

Share to Radiotherapy, Adjuvant

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Source

Open in PubMed Open full text

Identifiers

PMID: 26416160
DOI: 10.1111/his.12878
PMCID: PMC5650229

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy.PMID 26416160Read ↗

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