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Article

Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer.

Cancer cell - 11 Mar 2024

Cords Lena, Engler Stefanie, Haberecker Martina, Rüschoff Jan Hendrik, Moch Holger, de Souza Natalie, Bodenmiller Bernd

Abstract excerpt

Despite advances in treatment, lung cancer survival rates remain low. A better understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts (CAFs) within the tumor microenvironment will support the development of personalized therapies. We report a spatially resolved single-cell imaging mass cytometry (IMC) analysis of CAFs in a non-small cell lung cancer cohort of 1,070 patients. We...

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Identifiers

PMID: 38242124
DOI: 10.1016/j.ccell.2023.12.021
PMCID: PMC10929690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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