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Article

Mutated <i>BCR-ABL</i> Generates Immunogenic T-cell Epitopes in CML Patients

22 Aug 2012

Abstract excerpt

PURPOSE: Characterization of an approach to identify leukemia neoantigens arising in the context of drug resistance. EXPERIMENTAL DESIGN: We assessed whether leukemia neoantigens could be generated from drug-resistant mutations in BCR-ABL after imatinib relapse in patients with chronic myelogenous leukemia (CML). RESULTS: We computationally predicted that approximately 70 peptides derived from 26 BCR-ABL...

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PMID: 22912393
DOI: 10.1158/1078-0432.ccr-12-1182

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