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Article

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy.

Nature medicine - 1 Nov 2019

Chowell Diego, Krishna Chirag, Pierini Federica, Makarov Vladimir, Rizvi Naiyer A, Kuo Fengshen, Morris Luc G T, Riaz Nadeem, Lenz Tobias L, Chan Timothy A

Abstract excerpt

Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes underlies successful immunologic control of both infectious disease and cancer. The divergent allele advantage hypothesis dictates that an HLA-I genotype with two alleles with sequences that are more divergent enables presentation of more diverse immunopeptidomes1-3. However, the effect of sequence divergence between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31700181
DOI: 10.1038/s41591-019-0639-4
PMCID: PMC7938381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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