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Article

HLA-B evolutionary divergence is associated with outcomes after SARS-CoV-2 infection.

Human immunology - 1 Dec 2022

Hernandez Patricia V, Duffy Brian, Hock Karl, Farnsworth Christopher, Schindler Emily, Liu Chang

Abstract excerpt

We examined the correlation between class I HLA evolutionary divergence (HED), a surrogate for the capacity to present different peptides, and the outcomes of 234 adult inpatients with confirmed SARS-CoV-2 infection. Genomic DNA was extracted from peripheral blood and genotyped by next-generation sequencing (NGS). HED scores for HLA class I (HLA-A, -B, and -C) genotypes were calculated using Grantham's distance....

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Identifiers

PMID: 36109290
DOI: 10.1016/j.humimm.2022.09.004
PMCID: PMC9464580

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