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Article

SIRT7 and p53 interaction in embryonic development and tumorigenesis

2 Jan 2024

Abstract excerpt

p53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metabolic, oxidative, and genotoxic stress. In the recent years, mammalian Sirtuin 7 (SIRT7) has emerged as a pivotal regulator of p53, fine-tuning its activity in a...

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PMID: 38234684
DOI: 10.3389/fcell.2023.1281730

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