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Article

Sirtuins and Cancer: Role in the Epithelial‐Mesenchymal Transition

1 Jan 2016

Abstract excerpt

The human sirtuins (SIRT1-SIRT7) enzymes are a highly conserved family of NAD(+)-dependent histone deacetylases, which play a critical role in the regulation of a large number of metabolic pathways involved in stress response and aging. Cancer is an age-associated disease, and sirtuins may have a considerable impact on a plethora of processes that regulate tumorigenesis. In particular, growing evidence suggests...

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PMID: 27379175
DOI: 10.1155/2016/3031459

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