Article
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Cancer cell - 7 Oct 2008
Wang Rui-Hong, Sengupta Kundan, Li Cuiling, Kim Hyun-Seok, Cao Liu, Xiao Cuiying, Kim Sangsoo, Xu Xiaoling, Zheng Yin, Chilton Beverly, Jia Rong, Zheng Zhi-Ming, Appella Ettore, Wang Xin Wei, Ried Thomas, Deng Chu-Xia
Abstract excerpt
In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin silencing, longevity, and genome stability. Here we mutated the Sirt1 gene, a homolog of yeast Sir2, in mice to study its function. We show that a majority of SIRT1 null embryos die between E9.5 and E14.5, displaying altered histone modification, impaired DNA damage response, and reduced ability to repair DNA damage. We...
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