Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.

Circulation research - 28 Mar 2008

Vakhrusheva Olesya, Smolka Christian, Gajawada Praveen, Kostin Sawa, Boettger Thomas, Kubin Thomas, Braun Thomas, Bober Eva

Abstract excerpt

Sirt7 is a member of the mammalian sirtuin family consisting of 7 genes, Sirt1 to Sirt7, which all share a homology to the founding family member, the yeast Sir2 gene. Most sirtuins are supposed to act as histone/protein deacetylases, which use oxidized NAD in a sirtuin-specific, 2-step deacetyla...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cardiomegaly
Share to Cardiomyopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type III

Share to Fibrosis

Share to Myocarditis

Share to Myocytes, Cardiac

Share to Sirtuins

Source

Identifiers

PMID: 18239138
DOI: 10.1161/CIRCRESAHA.107.164558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18239138-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.PMID 18239138Read ↗

Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failureSemantic proximity Read ↗

The role of sirtuins in cardiac diseaseSemantic proximity Read ↗

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70Semantic proximity Read ↗

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7Semantic proximity Read ↗

Emerging beneficial roles of sirtuins in heart failureSemantic proximity Read ↗

SIRT7 and p53 interaction in embryonic development and tumorigenesisSemantic proximity Read ↗

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient miceSemantic proximity Read ↗

Silent information regulator, Sirtuin 1, and age‐related diseasesSemantic proximity Read ↗

SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar FunctionsSemantic proximity Read ↗

Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 responseSemantic proximity Read ↗

SIRT1: Regulator of p53 DeacetylationSemantic proximity Read ↗

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.