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Sirtuins at the crossroads of stemness, aging, and cancer

10 Oct 2017

Abstract excerpt

Sirtuins are stress-responsive proteins that direct various post-translational modifications (PTMs) and as a result, are considered to be master regulators of several cellular processes. They are known to both extend lifespan and regulate spontaneous tumor development. As both aging and cancer are associated with altered stem cell function, the possibility that the involvement of sirtuins in these events is...

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PMID: 28994177
DOI: 10.1111/acel.12685

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