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Article

Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer

18 Feb 2014

Abstract excerpt

SIRT7 belongs to the Sirtuin family of NAD-dependent enzymes, the members of which play diverse roles in aging, metabolism, and disease biology. Increased SIRT7 expression is observed in human cancers and growing evidence suggests important SIRT7 functions in fundamental cellular programs with an impact on oncogenic transformation and tumor biology. SIRT7 associates with chromatin, where it catalyzes selective...

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PMID: 24536059
DOI: 10.1158/1078-0432.ccr-13-1547

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