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Article

Inherited predisposition to myeloproliferative neoplasms

14 May 2013

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are haematological disorders characterized by an overproduction of mature myeloid cells with a tendency to transform to acute myeloid leukaemia. Clonal proliferation of myeloid progenitor cells is driven by somatically acquired mutations, most notably JAK2 V617F, but there are important features relating to pathogenesis and phenotypic diversity that cannot be explained by...

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PMID: 23926457
DOI: 10.1177/2040620713489144

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