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Article

The roles of sex and genetics in the MPN.

International review of cell and molecular biology - 1 Jan 2022

Moliterno Alison R, Braunstein Evan M

Abstract excerpt

The Philadelphia chromosome negative myeloproliferative neoplasms(MPNs), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are acquired hematopoietic stem cell disorders driven by activating mutations of intracellular signal transduction pathways that control the production of circulating blood cells. The MPN are characterized clinically by marked variation in degrees of...

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Identifiers

PMID: 35153002
DOI: 10.1016/bs.ircmb.2021.08.001

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