Article
Clinical associations with a polygenic predisposition to benign lower white blood cell counts.
Nature communications - 22 Apr 2024
Mosley Jonathan D, Shelley John P, Dickson Alyson L, Zanussi Jacy, Daniel Laura L, Zheng Neil S, Bastarache Lisa, Wei Wei-Qi, Shi Mingjian, Jarvik Gail P, Rosenthal Elisabeth A, Khan Atlas, Sherafati Alborz, Kullo Iftikhar J, Walunas Theresa L, Glessner Joseph, Hakonarson Hakon, Cox Nancy J, Roden Dan M, Frangakis Stephan G, Vanderwerff Brett, Stein C Michael, Van Driest Sara L, Borinstein Scott C, Shu Xiao-Ou, Zawistowski Matthew, Chung Cecilia P, Kawai Vivian K
Abstract excerpt
Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count (PGSWBC) comprising single nucleotide...
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