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Article

Cardiac macrophages in maintaining heart homeostasis and regulating ventricular remodeling of heart diseases.

Frontiers in immunology - 1 Jan 2024

Kang Mengjie, Jia Hui, Feng Mei, Ren Haolin, Gao Junjia, Liu Yueyang, Zhang Lu, Zhou Ming-Sheng

Abstract excerpt

Macrophages are most important immune cell population in the heart. Cardiac macrophages have broad-spectrum and heterogeneity, with two extreme polarization phenotypes: M1 pro-inflammatory macrophages (CCR2-ly6Chi) and M2 anti-inflammatory macrophages (CCR2-ly6Clo). Cardiac macrophages can reshape their polarization states or phenotypes to adapt to their surrounding microenvironment by altering metabolic...

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Identifiers

PMID: 39372400
DOI: 10.3389/fimmu.2024.1467089
PMCID: PMC11449765

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