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Article

M2b Macrophages Regulate Cardiac Fibroblast Activation and Alleviate Cardiac Fibrosis After Reperfusion Injury.

Circulation journal : official journal of the Japanese Circulation Society - 25 Mar 2020

Yue Yuan, Huang Suiqing, Wang Lexun, Wu Zixuan, Liang Mengya, Li Huayang, Lv Linhua, Li Wei, Wu Zhongkai

Abstract excerpt

BACKGROUND: Macrophages play an important role in the development of cardiac fibrosis. However, the roles of different macrophage subtypes in cardiac fibroblast (CF) activation and cardiac fibrosis are unknown. METHODS AND RESULTS: Bone marrow-derived macrophages (BMDMs) were treated with different stimuli to induce differentiation into M1, M2a, M2b, and M2c macrophage subtypes. CFs were co-cultured with...

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Identifiers

PMID: 32161201
DOI: 10.1253/circj.CJ-19-0959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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