Resident cardiac macrophages mediate adaptive myocardial remodeling.

doi:10.1016/j.immuni.2021.07.003

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Article

Resident cardiac macrophages mediate adaptive myocardial remodeling.

Immunity - 14 Sept 2021

Wong Nicole R, Mohan Jay, Kopecky Benjamin J, Guo Shuchi, Du Lixia, Leid Jamison, Feng Guoshuai, Lokshina Inessa, Dmytrenko Oleksandr, Luehmann Hannah, Bajpai Geetika, Ewald Laura, Bell Lauren, Patel Nikhil, Bredemeyer Andrea, Weinheimer Carla J, Nigro Jessica M, Kovacs Attila, Morimoto Sachio, Bayguinov Peter O, Fisher Max R, Stump W Tom, Greenberg Michael, Fitzpatrick James A J, Epelman Slava, Kreisel Daniel, Sah Rajan, Liu Yongjian, Hu Hongzhen, Lavine Kory J

Abstract excerpt

Cardiac macrophages represent a heterogeneous cell population with distinct origins, dynamics, and functions. Recent studies have revealed that C-C Chemokine Receptor 2 positive (CCR2+) macrophages derived from infiltrating monocytes regulate myocardial inflammation and heart failure pathogenesis. Comparatively little is known about the functions of tissue resident (CCR2-) macrophages. Herein, we identified an...

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PMID: 34320366
DOI: 10.1016/j.immuni.2021.07.003
PMCID: PMC8446343

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