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Article

CXCR7 suppression modulates macrophage phenotype and function to ameliorate post-myocardial infarction injury.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 May 2020

Zhang Junshi, Zhang Ying, Xin Shifeng, Wu Min, Zhang Yaling, Sun Lihua

Abstract excerpt

OBJECTIVE: Myocardial infarction (MI) is one of the primary causes leading to heart failure in coronary artery disease. However, the mechanisms of macrophage that dominate pathogenesis of MI remain unclear. METHODS: Mice were induced with MI and pretreated with adenovirus containing indicated shRNA. Post-MI injuries were evaluated by echocardiography. BMDMs and post-MI LV macrophages were used to assess the...

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PMID: 32170348
DOI: 10.1007/s00011-020-01335-z

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