Article
Polymorphism of Opioid Receptors μ1 in Highly Hypnotizable Subjects.
The International journal of clinical and experimental hypnosis - 1 Jan 2000
Presciuttini Silvano, Curcio Michele, Sciarrino Rosalia, Scatena Fabrizio, Jensen Mark P, Santarcangelo Enrica L
Abstract excerpt
The possible cooperation between hypnotizability-related and placebo mechanisms in pain modulation has not been consistently assessed. Here, we investigate possible genetic bases for such cooperation. The OPRM1 gene, which encodes the μ1 opioid receptor-the primary site of action for endogenous and exogenous opioids-is polymorphic in the general population for the missense mutation Asn40Asp (A118G, rs1799971)....
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