S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium.

doi:10.1093/rheumatology/keae020

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Article

S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium.

Rheumatology (Oxford, England) - 1 Jan 2025

van Kooten Nienke J T, Blom Arjen B, Teunissen van Manen Iris J, Theeuwes Wessel F, Roth Johannes, Gorris Mark A J, Walgreen Birgitte, Sloetjes Annet W, Helsen Monique M, Vitters Elly L, van Lent Peter L E M, Koëter Sander, van der Kraan Peter M, Vogl Thomas, van den Bosch Martijn H J

Abstract excerpt

OBJECTIVES: Macrophages are key orchestrators of the osteoarthritis (OA)-associated inflammatory response. Macrophage phenotype is dependent on environmental cues like the inflammatory factor S100A8/A9. Here, we investigated how S100A9 exposure during monocyte-to-macrophage differentiation affects macrophage phenotype and function. METHODS: OA synovium cellular composition was determined using flow cytometry and...

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Identifiers

PMID: 38216750
DOI: 10.1093/rheumatology/keae020
PMCID: PMC11701306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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