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Article

Phenotypic alteration of macrophages during osteoarthritis: a systematic review.

Arthritis research & therapy - 10 Apr 2021

Zhu Xiaobo, Lee Chien-Wei, Xu Hongtao, Wang Yu-Fan, Yung Patrick S H, Jiang Yangzi, Lee Oscar K

Abstract excerpt

OBJECTIVE: Osteoarthritis (OA) has long been regarded as a disease of cartilage degeneration, whereas mounting evidence implies that low-grade inflammation contributes to OA. Among inflammatory cells involved, macrophages play a crucial role and are mediated by the local microenvironment to exhibit different phenotypes and polarization states. Therefore, we conducted a systematic review to uncover the phenotypic...

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Identifiers

PMID: 33838669
DOI: 10.1186/s13075-021-02457-3
PMCID: PMC8035781

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