Article
Macrophage plasticity and polarization: in vivo veritas.
The Journal of clinical investigation - 1 Mar 2012
Sica Antonio, Mantovani Alberto
Abstract excerpt
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of activation states. Progress has now been made in defining the signaling pathways, transcriptional networks, and epigenetic...
Topics
- Animals
- Cell Lineage
- Humans
- Inflammation
- Macrophage Activation
- Macrophages
- Mice
- Models, Biological
- Oxygen
- Phenotype
- Signal Transduction
- Transcription Factors