Ultrasensitive detection of cancer-associated nucleic acids and mutations by primer exchange reaction-based signal amplification and flow cytometry.

Abstract excerpt

The detection of cancer-associated nucleic acids and mutations through liquid biopsy has emerged as a highly promising non-invasive approach for early cancer detection and monitoring. In this study, we report the development of primer exchange reaction (PER) based signal amplification strategy that enables the rapid, sensitive and specific detection of nucleic acids bearing cancer specific single nucleotide...

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• Biosensing Techniques
• Circulating Tumor DNA
• Class I Phosphatidylinositol 3-Kinases
• DNA, Neoplasm
• Limit of Detection