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Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression

10 Jan 2024

Abstract excerpt

Dysregulation of the alternative pathway (AP) of the complement system is a significant contributor to age-related macular degeneration (AMD), a primary cause of irreversible vision loss worldwide. Here, we assess the contribution of the liver-produced complement factor H-related 4 protein (FHR-4) to AMD initiation and course of progression. We show that FHR-4 variation in plasma and at the primary location of...

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PMID: 38200010
DOI: 10.1038/s41467-023-44605-0

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