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Article

Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration.

Nature communications - 7 Feb 2020

Cipriani Valentina, Lorés-Motta Laura, He Fan, Fathalla Dina, Tilakaratna Viranga, McHarg Selina, Bayatti Nadhim, Acar İlhan E, Hoyng Carel B, Fauser Sascha, Moore Anthony T, Yates John R W, de Jong Eiko K, Morgan B Paul, den Hollander Anneke I, Bishop Paul N, Clark Simon J

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants at the chromosome 1q31.3 encompassing the complement factor H (CFH, FH) and CFH related genes (CFHR1-5) are major determinants of AMD susceptibility, but their molecular consequences remain unclear. Here we demonstrate that FHR-4 plays a prominent role in AMD pathogenesis. We show that systemic FHR-4 levels are elevated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32034129
DOI: 10.1038/s41467-020-14499-3
PMCID: PMC7005798

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Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration.PMID 32034129Read ↗

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