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Article

Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations.

American journal of human genetics - 5 Aug 2021

Cipriani Valentina, Tierney Anna, Griffiths John R, Zuber Verena, Sergouniotis Panagiotis I, Yates John R W, Moore Anthony T, Bishop Paul N, Clark Simon J, Unwin Richard D

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of vision loss; there is strong genetic susceptibility at the complement factor H (CFH) locus. This locus encodes a series of complement regulators: factor H (FH), a splice variant factor-H-like 1 (FHL-1), and five factor-H-related proteins (FHR-1 to FHR-5), all involved in the regulation of complement factor C3b turnover. Little is known about how...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34260948
DOI: 10.1016/j.ajhg.2021.05.015
PMCID: PMC8387294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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