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Article

TIMely connections: APOE4, aging, and Alzheimer's.

Immunity - 9 Jan 2024

Li Qingyun

Abstract excerpt

How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.

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Identifiers

PMID: 38198855
DOI: 10.1016/j.immuni.2023.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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