Article
Potential and Uncertainties of RejectClass in Acute Kidney Graft Dysfunction: An Independent Validation Study.
Transplantation - 1 May 2024
von Samson-Himmelstjerna Friedrich A, Kakavand Nassim, Gleske Charlotte, Schraml Florian, Basta Agathe A, Braunisch Matthias C, Bräsen Jan H, Schmitz Jessica, Kraus Daniel, Weinmann-Menke Julia, Zacharias Helena U, Vaulet Thibaut, Naesens Maarten, Krautter Markus, Schwenger Vedat, Esser Grit, Kolbrink Benedikt, Amann Kerstin, Holzmann-Littig Christopher, Echterdiek Fabian, Kunzendorf Ulrich, Renders Lutz, Schulte Kevin, Heemann Uwe
Abstract excerpt
BACKGROUND: Kidney graft rejections are classified based on the Banff classification. The RejectClass algorithm, initially derived from a cohort comprising mostly protocol biopsies, identifies data-driven phenotypes of acute rejection and chronic pathology using Banff lesion scores. It also provides composite scores for inflammation activity and chronicity. This study independently evaluates the performance of...
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