Article
Diagnosing rejection in renal transplants: a comparison of molecular- and histopathology-based approaches.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Aug 2009
Reeve J, Einecke G, Mengel M, Sis B, Kayser N, Kaplan B, Halloran P F
Abstract excerpt
The transcriptome has considerable potential for improving biopsy diagnoses. However, to realize this potential the relationship between the molecular phenotype of disease and histopathology must be established. We assessed 186 consecutive clinically indicated kidney transplant biopsies using microarrays, and built a classifier to distinguish rejection from nonrejection using predictive analysis of microarrays...
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