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Article

Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery.

Journal of the American Society of Nephrology : JASN - 1 Aug 2021

Buscher Konrad, Heitplatz Barbara, van Marck Veerle, Song Jian, Loismann Sophie, Rixen Rebecca, Hüchtmann Birte, Kurian Sunil, Ehinger Erik, Wolf Dennis, Ley Klaus, Pavenstädt Hermann, Reuter Stefan

Abstract excerpt

BACKGROUND: In transplant medicine, clinical decision making largely relies on histology of biopsy specimens. However, histology suffers from low specificity, sensitivity, and reproducibility, leading to suboptimal stratification of patients. We developed a histology-independent immune framework of kidney graft homeostasis and rejection. METHODS: We applied tailored RNA deconvolution for leukocyte enumeration and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34078665
DOI: 10.1681/ASN.2020121685
PMCID: PMC8455252

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