Article
Identification of liver transplant biopsy phenotypes associated with distinct liver biological markers and allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jun 2024
Demir Zeynep, Raynaud Marc, Aubert Olivier, Debray Dominique, Sebagh Mylène, Duong Van Huyen Jean-Paul, Del Bello Arnaud, Jolivet Nicolas Congy, Paradis Valérie, Durand François, Muratot Sophie, Lozach Cécile, Chardot Christophe, Francoz Claire, Kamar Nassim, Sarnacki Sabine, Coilly Audrey, Samuel Didier, Vibert Eric, Féray Cyrille, Lefaucheur Carmen, Loupy Alexandre
Abstract excerpt
The intricate association between histologic lesions and circulating antihuman leucocyte antigen donor-specific antibodies (DSA) in liver transplantation (LT) requires further clarification. We conducted a probabilistic, unsupervised approach in a comprehensively well-annotated LT cohort to identify clinically relevant archetypes. We evaluated 490 pairs of LT biopsies with DSA testing from 325 recipients...
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