Article
Innovative Drug and Prodrug Candidates in Cancer Treatment Targeting TP53 Mutations: Challenge and Hope.
Drug development research - 1 Apr 2026
Al-Zoubi Raed M, Elaarag Mai, Zarour Ayman A, Garada Khalil, Al-Zoubi Sally R, Fares Zainab E, Al-Qudimat Ahmad R, Shkoor Mohanad, Khan Abbas, Sawali Mona A, Bawadi Hiba, Zakaria Zain Z, Zoubi Mazhar Al, Agouni Abdelali, Alrumaihi Khalid
Abstract excerpt
The TP53 gene encodes the tumor suppressor protein 53, which is critical for maintaining genomic stability and preventing tumorigenesis. Mutations in TP53, particularly missense mutations, have a substantial impact on cancer progression because they give gain-of-function features that enhance proliferation, metastasis, and treatment resistance. This review examines the mechanisms underlying p53 mutations,...
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