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Article

Genome-wide classification of epigenetic activity reveals regions of enriched heritability in immune-related traits.

Cell genomics - 10 Jan 2024

Stricker Miriam, Zhang Weijiao, Cheng Wei-Yi, Gazal Steven, Dendrou Calliope, Nahkuri Satu, Palamara Pier Francesco

Abstract excerpt

Epigenetics underpins the regulation of genes known to play a key role in the adaptive and innate immune system (AIIS). We developed a method, EpiNN, that leverages epigenetic data to detect AIIS-relevant genomic regions and used it to detect 2,765 putative AIIS loci. Experimental validation of one of these loci, DNMT1, provided evidence for a novel AIIS-specific transcription start site. We built a genome-wide...

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Identifiers

PMID: 38190103
DOI: 10.1016/j.xgen.2023.100469
PMCID: PMC10794845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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