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Article

Intratumor genetic heterogeneity and head and neck cancer relapse.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Feb 2024

Pierik A S, Poell J B, Brink A, Stigter-van Walsum M, de Roest R H, Poli T, Yaromin A, Lambin P, Leemans C R, Brakenhoff R H

Abstract excerpt

BACKGROUND: Head and neck squamous cell carcinomas are treated by surgery, radiotherapy (RT), chemoradiotherapy (CRT) or combinations thereof, but locoregional recurrences (LRs) occur in 30-40% of treated patients. We have previously shown that in approximately half of the LRs after CRT, cancer driver mutations are not shared with the index tumor. AIM: To investigate two possible explanations for these...

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Identifiers

PMID: 38185257
DOI: 10.1016/j.radonc.2024.110087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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