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Article

Clinical implication of genetic intratumor heterogeneity for targeted therapy in head and neck cancer.

Acta oncologica (Stockholm, Sweden) - 1 Dec 2023

Gram Signe Buhl, Alosi Daniela, Bagger Frederik Otzen, Østrup Olga, von Buchwald Christian, Friborg Jeppe, Wessel Irene, Vogelius Ivan Richter, Rohrberg Kristoffer, Rasmussen Jacob Høygaard

Abstract excerpt

BACKGROUND: Genomic profiling is increasingly used both in therapeutic decision-making and as inclusion criteria for trials testing targeted therapies. However, the mutational landscape may vary across different areas of a tumor and intratumor heterogeneity will challenge treatments or clinical decisions based on single tumor biopsies. The purpose of this study was to assess the clinical relevance of genetic...

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PMID: 37902999
DOI: 10.1080/0284186X.2023.2272293

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