Article
The degree of intratumor mutational heterogeneity varies by primary tumor sub-site.
Oncotarget - 10 May 2016
Ledgerwood Levi G, Kumar Dhruv, Eterovic Agda Karina, Wick Jo, Chen Ken, Zhao Hao, Tazi Loubna, Manna Pradip, Kerley Spencer, Joshi Radhika, Wang Lin, Chiosea Simion I, Garnett James David, Tsue Terance Ted, Chien Jeremy, Mills Gordon B, Grandis Jennifer Rubin, Thomas Sufi Mary
Abstract excerpt
In an era where mutational profiles inform treatment options, it is critical to know the extent to which tumor biopsies represent the molecular profile of the primary and metastatic tumor. Head and neck squamous cell carcinoma (HNSCC) arise primarily in the mucosal lining of oral cavity and oropharynx. Despite aggressive therapy the 5-year survival rate is at 50%. The primary objective of this study is to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.