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Article

Molecular Characterization of Locally Relapsed Head and Neck Cancer after Concomitant Chemoradiotherapy

22 Aug 2019

Abstract excerpt

PURPOSE: To investigate the pathobiological origin of local relapse after chemoradiotherapy, we studied genetic relationships of primary tumors (PT) and local relapses (LR) of patients treated with chemoradiotherapy. EXPERIMENTAL DESIGN: First, low-coverage whole genome sequencing was performed on DNA from 44 biopsies of resected head and neck squamous cell carcinoma (HNSCC) specimens (median 3 biopsies/tumor) to...

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PMID: 31439582
DOI: 10.1158/1078-0432.ccr-19-0628

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