Article

Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma

2024-04-30

Abstract excerpt

Oral squamous cell carcinoma (OSCC), which is characterized by high rates of recurrence and metastasis, is a prevalent and burdensome form of head and neck cancer. Genomic heterogeneity and clonal evolution play critical roles in OSCC progression and therapeutic resistance. This review comprehensively examines the current understanding of genomic heterogeneity in OSCC, focusing on intratumoral heterogeneity and cl...

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Literature Corpus work: 34bdbb25-2621-5ebc-945f-2f35faf493cc
DOI: 10.1016/j.oor.2024.100469

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