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Article

Permitted daily exposure limits for noteworthy N-nitrosamines.

Environmental and molecular mutagenesis - 1 Jun 2021

Johnson George E, Dobo Krista, Gollapudi Bhaskar, Harvey Jim, Kenny Julia, Kenyon Michelle, Lynch Anthony, Minocherhomji Sheroy, Nicolette John, Thybaud Veronique, Wheeldon Ryan, Zeller Andreas

Abstract excerpt

A genotoxic carcinogen, N-nitrosodimethylamine (NDMA), was detected as a synthesis impurity in some valsartan drugs in 2018, and other N-nitrosamines, such as N-nitrosodiethylamine (NDEA), were later detected in other sartan products. N-nitrosamines are pro-mutagens that can react with DNA following metabolism to produce DNA adducts, such as O6 -alkyl-guanine. The adducts can result in DNA replication miscoding...

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PMID: 34089278
DOI: 10.1002/em.22446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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