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Article

Overexpression of eis without a mutation in promoter region of amikacin- and kanamycin-resistant Mycobacterium tuberculosis clinical strain.

Annals of clinical microbiology and antimicrobials - 16 Jul 2018

Sowajassatakul Angkanang, Prammananan Therdsak, Chaiprasert Angkana, Phunpruch Saranya

Abstract excerpt

BACKGROUND: Aminoglycosides such as amikacin and kanamycin are effective injectable second-line drugs for treatment of multidrug-resistant tuberculosis. Molecular mechanisms underlying aminoglycoside resistance are not well understood. We have previously identified the amikacin- and kanamycin-resistant M. tuberculosis MT433 clinical strain, of which all known mutations related to resistance have not been found....

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Identifiers

PMID: 30008266
DOI: 10.1186/s12941-018-0285-6
PMCID: PMC6047124

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