The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis.

doi:10.1192/j.eurpsy.2023.2480

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Article

The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis.

European psychiatry : the journal of the Association of European Psychiatrists - 5 Jan 2024

Clougher Derek, Segura Àlex G, Forte Maria F, Mezquida Gisela, Cuesta Manuel J, Vieta Eduard, Amoretti Silvia, Lobo Antonio, González-Pinto Ana, Díaz-Caneja Covadonga M, Roldán Alexandra, Fico Giovanna, de la Serna Elena, Bergé Daniel, Gassó Patricia, Rodriguez Natalia, Verdolini Norma, Tortorella Alfonso, Menculini Giulia, Ribasés Marta, Bernardo Miguel, Mas Sergi

Abstract excerpt

BACKGROUND: Polygenic risk scores for educational attainment (PRSEA), cognitive reserve (CR), and clinical symptoms are associated with functioning in first-episode psychosis (FEP). Nevertheless, the mechanisms underlying their complex interaction are yet to be explored. This study assessed the mediating role of CR and clinical symptoms, both negative (NS) and positive (PS), on the interrelationship between PRSEA...

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Topics

Humans
Psychotic Disorders
Cognitive Reserve

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Adult

Young Adult

Educational Status

Mediation Analysis

Genome-Wide Association Study

Adolescent

Multifactorial Inheritance

Genetic Predisposition to Disease

Source

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Identifiers

PMID: 38178712
DOI: 10.1192/j.eurpsy.2023.2480
PMCID: PMC11795430

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