Article
Cognitive intermediate phenotype and genetic risk for psychosis.
Current opinion in neurobiology - 1 Feb 2016
Mark Winifred, Toulopoulou Timothea
Abstract excerpt
Intermediate phenotypes (IPs) are defined as measurable liability traits underlying complex phenotypes, posited to be more genetically tractable than the phenotypes themselves. Here we review evidence for cognition as an IP of psychosis, and highlight topical advances in the literature: first, heritability estimation of cognitive abilities using genomewide complex-trait analysis; second, evidence that cognition...
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