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Article

Association between cognitive phenotype in unaffected siblings and prospective 3- and 6-year clinical outcome in their proband affected by psychosis.

Psychological medicine - 1 Aug 2021

Burger Thijs J, Schirmbeck Frederike, Vermeulen Jentien M, Quee Piotr J, de Koning Mariken B, Bruggeman Richard, de Haan Lieuwe

Abstract excerpt

BACKGROUND: Cognitive alterations are a central and heterogeneous trait in psychotic disorders, driven by environmental, familial and illness-related factors. In this study, we aimed to prospectively investigate the impact of high familial risk for cognitive alterations, unconfounded by illness-related factors, on symptomatic outcomes in patients. METHODS: In total, 629 probands with non-affective psychosis and...

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Identifiers

PMID: 32290874
DOI: 10.1017/S0033291720000719

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